I-Phenolibaluleke kakhulu i-organic material eluhlaza, esetshenziswa kabanzi ekukhiqizeni imikhiqizo ehlukahlukene yamakhemikhali, njengepulasitiki, irabha, imithi, isibulala-zinambuzane, njll. Ngakho-ke, kubaluleke kakhulu ukwazi izinto zokusetshenziswa ze-phenol.

Izinto zokusetshenziswa zokukhiqiza i-phenol ikakhulukazi zifaka i-benzene, i-methanol ne-sulfuric acid. I-Benzene iyimpahla eluhlaza ebaluleke kakhulu, engasetshenziswa ukukhiqiza izinhlobo eziningi zemikhiqizo yamakhemikhali, njenge-phenol, i-aniline, i-acetophenone njalonjalo. I-Methanol iyi-organic material eluhlaza ebalulekile, engasetshenziswa ukukhiqiza izinhlanganisela ezihlukahlukene namaqembu asebenzayo aqukethe umoya-mpilo. I-Sulfuric acid iyi-asidi ebalulekile ye-inorganic, esetshenziswa kakhulu embonini yamakhemikhali nakwezinye izimboni.

Inqubo yokukhiqiza i-phenol nge-benzene, i-methanol ne-sulfuric acid iyinkimbinkimbi kakhulu. Okokuqala, i-benzene ne-methanol zisabela ngaphansi kwesenzo se-catalyst ukukhiqiza i-cumene. Khona-ke, i-cumene i-oxidized phambi komoya ukuze yakhe i-cumene hydroperoxide. Ekugcineni, i-cumene hydroperoxide isabela nge-sulfuric acid ehlanjululwe ukukhiqiza i-phenol ne-acetone.

Enqubweni yokukhiqiza i-phenol, ukukhethwa kwe-catalyst kubaluleke kakhulu. Ama-catalyst asetshenziswa kakhulu afaka i-aluminium chloride, i-sulfuric acid ne-phosphoric acid. Ngaphezu kwalokho, izimo zenqubo ezifana nokushisa, ukucindezela nokugxila nazo zithinta isivuno kanye nekhwalithi yomkhiqizo.

Ngokuvamile, izinto zokusetshenziswa zokukhiqiza i-phenol ziyinkimbinkimbi, futhi izimo zenqubo ziqinile. Ukuze uthole imikhiqizo yekhwalithi ephezulu nephezulu, kuyadingeka ukulawula ngokuqinile ikhwalithi yempahla eluhlaza kanye nezimo zenqubo. Ngaphezu kwalokho, kuyadingeka futhi ukucabangela ukuvikelwa kwemvelo nokuphepha ohlelweni lokukhiqiza. Ngakho-ke, lapho sisebenzisa i-phenol njengempahla eluhlaza ukukhiqiza imikhiqizo ehlukahlukene yamakhemikhali, kufanele sinake lezi zici ukuze siqinisekise ukuthi singathola imikhiqizo yekhwalithi ephezulu nekhiqiza kakhulu kuyilapho sivikela imvelo nokuphepha.